In 1496, King Manuel I ordered a monastery to be built here. The original Ermida do Restelo hermitage was found by Henry the Navigator in 1450. The construction of the monastery and church began on 6 January 1501 and it took 100 years to complete this building. A 5% tax on commerce from Africa and the Orient was applied to gather money for the construction of this project. The only products which were tax free at that time (tax would go to the Crown) were pepper, cinnamon and cloves.
After the initial construction of the monastery King Manuel I selected the Hieronymites order of monks to reside in the building. The Hieronymites order were dedicated to Saint Jerome, hence name of the monastery. He was a 5th century scholar who translated the original bible into Latin. The Order of Hieronymite occupied this monastery till 1833. Then this religious orders were dissolved and the monastery was abandoned.
From the upper level of the cloister, it offers a great view of the stained glass windows and the slender columns of the church.