Sayyida Nafisa Mosque in Cairo is built over the tomb of Sayyida Nafisa. She was the great granddaughter of the Prophet Mohamed (PBUH), daughter of al-Hasan al-Anwar, the son of Zaid bin Hassan bin Imam Ali (A.S.). Nafisa moved to Cairo from Medina (Hejaz in the past, now Saudi Arabia) in 809 AD and died in Cairo in 824 AD. She married to Ishaq al-Mutamin, son of the sixth Shia Imam Jafar al-Sadiq.
It is said that this holy lady dug her own grave because she knew her time was getting nearer. Every day she would enter the grave and worship in it. She was not only known for her abstinence and piety but also for religious teachings. Imam al-Shafi was also one of her students (he is buried in Cairo too). This holy lady provided education for the young girls and women alike in her era.